Low-density lipoprotein receptor class A…

About Low-density lipoprotein receptor class A domain-containing protein 3

Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3) is a protein from Homo sapiens identified by UniProt accession Q86YD5, 345 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Low-density lipoprotein receptor class A domain-containing protein 3
UniProt accession	Q86YD5
Gene	LDLRAD3
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.49
lymphocyte percentage of leukocytes · score 0.42
blood protein measurement · score 0.40
neutrophil percentage of leukocytes · score 0.33
metabolite measurement · score 0.30
non-small cell lung carcinoma · score 0.09
gonorrhea · score 0.07
neoplasm · score 0.07
infection · score 0.04
infect · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YD5-F1	alphafold	PREDICTED	61.43	—

Amino-acid sequence (345 residues)

MWLLGPLCLL LSSAAESQLL PGNNFTNECN IPGNFMCSNG RCIPGAWQCD GLPDCFDKSD EKECPKAKSK CGPTFFPCAS GIHCIIGRFR CNGFEDCPDG SDEENCTANP LLCSTARYHC KNGLCIDKSF ICDGQNNCQD NSDEESCESS QEPGSGQVFV TSENQLVYYP SITYAIIGSS VIFVLVVALL ALVLHHQRKR NNLMTLPVHR LQHPVLLSRL VVLDHPHHCN VTYNVNNGIQ YVASQAEQNA SEVGSPPSYS EALLDQRPAW YDLPPPPYSS DTESLNQADL PPYRSRSGSA NSASSQAASS LLSVEDTSHS PGQPGPQEGT AEPRDSEPSQ GTEEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)