5'-nucleotidase domain-containing protein 4 (NT5DC4)

About 5'-nucleotidase domain-containing protein 4

5'-nucleotidase domain-containing protein 4 (NT5DC4) is a protein from Homo sapiens identified by UniProt accession Q86YG4, 428 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	5'-nucleotidase domain-containing protein 4
UniProt accession	Q86YG4
Gene	NT5DC4
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

Filippi syndrome · score 0.37
mean platelet volume · score 0.35
platelet count · score 0.33
matrix metalloproteinase 1 measurement · score 0.24
neutrophil count · score 0.21
gut microbiome measurement · score 0.20
genetic disorder · score 0.19
mean corpuscular volume · score 0.12
leukocyte count · score 0.10
birth measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YG4-F1	alphafold	PREDICTED	86.96	—

Amino-acid sequence (428 residues)

MPAWIFVNRS LALGKIRCFG FDMDYTLAAY KSPAYEALTF ELLLERLVCI GYPHEILRYT YDPTFPTRRL VFDELYGNLL KVDAHGNVLL GAYGFTFLSE AEIWSFYPSK FIQRDDLQCF YILNMLFNLP ETYLYACLVD FFSGCSRYTN CDTGYQHGNL FMSFRSLFQD VTDAMNNIHQ SGCLKKTLED LEKYVKKDPR LPILLGKMKE VGKVFLATNS SYNYTNAIMT YLFSISEAEA SGRPWRSYFD LIVVDTQKPH FFAEGLVLRQ VNTDSGKLHV GTYTGPHQHC AVYSGGSSDM VCELLGVRGM DILYIGDHIF GDILKSKKRQ GWRTCLVVPE LSWELDIWAQ EKERLEELKR LDTHLADIYQ HMDGSSCELQ VINFTKREIQ MPHESVVEQE QANLDPASCL LSCNQRSLPA KSCLSSAI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards