About Testis development-related protein
Testis development-related protein (TDRP) is a protein
from Homo sapiens identified by UniProt accession
Q86YL5, 185 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Testis development-related protein |
|---|
| UniProt accession | Q86YL5 |
|---|
| Gene | TDRP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 185 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (108)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- drug use measurement · score 0.29
- protein measurement · score 0.26
- fetal genotype effect measurement · score 0.25
- interleukin 4 measurement · score 0.25
- hematocrit · score 0.12
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- lymphocyte count · score 0.08
- spermatogenic failure 24 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YL5-F1 | alphafold | PREDICTED | 59.62 | — |
Amino-acid sequence (185 residues)
MWKLGRGRVL LDEPPEEEDG LRGGPPPAAA AAAQAQVQGA SFRGWKEVTS LFNKDDEQHL LERCKSPKSK GTNLRLKEEL KAEKKSGFWD NLVLKQNIQS KKPDEIEGWE PPKLALEDIS ADPEDTVGGH PSWSGWEDDA KGSTKYTSLA SSANSSRWSL RAAGRLVSIR RQSKGHLTDS PEEAE
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