Homer protein homolog 1 (HOMER1)

About Homer protein homolog 1

Homer protein homolog 1 (HOMER1) is a protein from Homo sapiens identified by UniProt accession Q86YM7, 354 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Homer protein homolog 1
UniProt accession	Q86YM7
Gene	HOMER1
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

bipolar disorder · score 0.39
bipolar I disorder · score 0.31
attention deficit hyperactivity disorder · score 0.30
thyroid gland adenocarcinoma · score 0.18
hepatocellular carcinoma · score 0.08
retinal ischemia · score 0.07
coronary artery disease · score 0.07
Autism · score 0.06
schizophrenia · score 0.04
Cirrhosis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YM7-F1	alphafold	PREDICTED	86.81	—

Amino-acid sequence (354 residues)

MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards