About G-protein-signaling modulator 1
G-protein-signaling modulator 1 (GPSM1) is a protein
from Homo sapiens identified by UniProt accession
Q86YR5, 675 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | G-protein-signaling modulator 1 |
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| UniProt accession | Q86YR5 |
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| Gene | GPSM1 |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.47
- glucose measurement · score 0.38
- diabetes mellitus · score 0.37
- HbA1c measurement · score 0.36
- myocardial infarction · score 0.35
- Drugs used in diabetes use measurement · score 0.33
- complication · score 0.27
- birth weight · score 0.26
- Insulinogenic index measurement · score 0.26
- BMI-adjusted waist-hip ratio · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YR5-F1 | alphafold | PREDICTED | 67.90 | — |
Amino-acid sequence (675 residues)
MAGPAPPVAD ELPGPAARRL YSRMEASCLE LALEGERLCK AGDFKTGVAF FEAAVQVGTE DLKTLSAIYS QLGNAYFYLK EHGRALEYHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG RFDEAAVCCQ RHLSIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNAANA TQDPGHLPPD VRETLCKASE FYERNLSLVK ELGDRAAQGR AYGNLGNTHY LLGNFTEATT FHKERLAIAK EFGDKAAERR AYSNLGNAHV FLGRFDVAAE YYKKTLQLSR QLRDQAVEAQ ACYSLGNTYT LLQDYERAAE YHLRHLLIAQ ELADRVGEGR ACWSLGNAYV SMGRPAQALT FAKKHLQISQ EIGDRHGELT ARMNVAQLQL VLGRLTSPAA SEKPDLAGYE AQGARPKRTQ RLSAETWDLL RLPLEREQNG DSHHSGDWRG PSRDSLPLPV RSRKYQEGPD AERRPREGSH SPLDSADVRV HVPRTSIPRA PSSDEECFFD LLTKFQSSRM DDQRCPLDDG QAGAAEATAA PTLEDRIAQP SMTASPQTEE FFDLIASSQS RRLDDQRASV GSLPGLRITH SNAGHLRGHG EPQEPGDDFF NMLIKYQSSR IDDQRCPPPD VLPRGPTMPD EDFFSLIQRV QAKRMDEQRV DLAGGPEQGA GGPPEPQQQC QPGAS
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