About Ras-related protein Rab-43
Ras-related protein Rab-43 (RAB43) is a protein
from Homo sapiens identified by UniProt accession
Q86YS6, 212 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Ras-related protein Rab-43 |
|---|
| UniProt accession | Q86YS6 |
|---|
| Gene | RAB43 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 212 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (36)
Diseases linked to this target (Open Targets).
- muscular dystrophy · score 0.08
- gonorrhea · score 0.07
- eosinophil count · score 0.06
- hemoglobin D disease · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.04
- hypertriglyceridemia 2 · score 0.04
- dominant beta-thalassemia · score 0.04
- sitosterolemia · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
- glycogen storage disease VI · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YS6-F1 | alphafold | PREDICTED | 84.83 | — |
Amino-acid sequence (212 residues)
MAGPGPGPGD PDEQYDFLFK LVLVGDASVG KTCVVQRFKT GAFSERQGST IGVDFTMKTL EIQGKRVKLQ IWDTAGQERF RTITQSYYRS ANGAILAYDI TKRSSFLSVP HWIEDVRKYA GSNIVQLLIG NKSDLSELRE VSLAEAQSLA EHYDILCAIE TSAKDSSNVE EAFLRVATEL IMRHGGPLFS EKSPDHIQLN SKDIGEGWGC GC
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