About Na(+)/citrate cotransporter
Na(+)/citrate cotransporter (SLC13A5) is a protein
from Homo sapiens identified by UniProt accession
Q86YT5, 568 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | Na(+)/citrate cotransporter |
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| UniProt accession | Q86YT5 |
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| Gene | SLC13A5 |
|---|
| Organism | Homo sapiens |
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| Length | 568 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (179)
Diseases linked to this target (Open Targets).
- undetermined early-onset epileptic encephalopathy · score 0.66
- developmental and epileptic encephalopathy · score 0.57
- citrate measurement · score 0.56
- genetic disorder · score 0.47
- calcium measurement · score 0.38
- amelocerebrohypohidrotic syndrome · score 0.37
- Hypoplastic amelogenesis imperfecta · score 0.37
- blood metabolite measurement · score 0.34
- Epileptic encephalopathy · score 0.33
- visual perception measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YT5-F1 | alphafold | PREDICTED | 86.05 | — |
Amino-acid sequence (568 residues)
MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKFVRCAY VIILMAIYWC TEVIPLAVTS LMPVLLFPLF QILDSRQVCV QYMKDTNMLF LGGLIVAVAV ERWNLHKRIA LRTLLWVGAK PARLMLGFMG VTALLSMWIS NTATTAMMVP IVEAILQQME ATSAATEAGL ELVDKGKAKE LPGSQVIFEG PTLGQQEDQE RKRLCKAMTL CICYAASIGG TATLTGTGPN VVLLGQMNEL FPDSKDLVNF ASWFAFAFPN MLVMLLFAWL WLQFVYMRFN FKKSWGCGLE SKKNEKAALK VLQEEYRKLG PLSFAEINVL ICFFLLVILW FSRDPGFMPG WLTVAWVEGE TKYVSDATVA IFVATLLFIV PSQKPKFNFR SQTEEERKTP FYPPPLLDWK VTQEKVPWGI VLLLGGGFAL AKGSEASGLS VWMGKQMEPL HAVPPAAITL ILSLLVAVFT ECTSNVATTT LFLPIFASMS RSIGLNPLYI MLPCTLSASF AFMLPVATPP NAIVFTYGHL KVADMVKTGV IMNIIGVFCV FLAVNTWGRA IFDLDHFPDW ANVTHIET
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