Myosin light chain kinase family member 4 (MYLK4)

About Myosin light chain kinase family member 4

Myosin light chain kinase family member 4 (MYLK4) is a protein from Homo sapiens identified by UniProt accession Q86YV6, 388 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Myosin light chain kinase family member 4
UniProt accession	Q86YV6
Gene	MYLK4
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (52)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.46
alkaline phosphatase measurement · score 0.41
appendicular lean mass · score 0.36
diffuse plaque measurement · score 0.33
reticulocyte count · score 0.31
reticulocyte measurement · score 0.26
vital capacity · score 0.26
peak expiratory flow · score 0.25
creatinine measurement · score 0.25
Immature Reticulocyte Fraction Measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YV6-F1	alphafold	PREDICTED	79.96	—

Amino-acid sequence (388 residues)

MLKVKRLEEF NTCYNSNQLE KMAFFQCREE VEKVKCFLEK NSGDQDSRSG HNEAKEVWSN ADLTERMPVK SKRTSALAVD IPAPPAPFDH RIVTAKQGAV NSFYTVSKTE ILGGGRFGQV HKCEETATGL KLAAKIIKTR GMKDKEEVKN EISVMNQLDH ANLIQLYDAF ESKNDIVLVM EYVDGGELFD RIIDESYNLT ELDTILFMKQ ICEGIRHMHQ MYILHLDLKP ENILCVNRDA KQIKIIDFGL ARRYKPREKL KVNFGTPEFL APEVVNYDFV SFPTDMWSVG VIAYMLLSGL SPFLGDNDAE TLNNILACRW DLEDEEFQDI SEEAKEFISK LLIKEKSWRI SASEALKHPW LSDHKLHSRL NAQKKKNRGS DAQDFVTK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards