About BLOC-2 complex member HPS6
BLOC-2 complex member HPS6 (HPS6) is a protein
from Homo sapiens identified by UniProt accession
Q86YV9, 775 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | BLOC-2 complex member HPS6 |
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| UniProt accession | Q86YV9 |
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| Gene | HPS6 |
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| Organism | Homo sapiens |
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| Length | 775 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (90)
Diseases linked to this target (Open Targets).
- Hermansky-Pudlak syndrome without pulmonary fibrosis · score 0.77
- Hermansky-Pudlak syndrome · score 0.67
- genetic disorder · score 0.19
- platelet storage pool deficiency · score 0.15
- Platelet storage pool disease · score 0.15
- Thrombocytopenia · score 0.11
- Abnormal bleeding · score 0.11
- Griscelli syndrome type 3 · score 0.10
- Griscelli disease · score 0.10
- Griscelli disease type 3 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YV9-F1 | alphafold | PREDICTED | 77.04 | — |
Amino-acid sequence (775 residues)
MKRSGTLRLL SDLSAFGGAA RLRELVAGDS AVRVRGSPDG RHLLLLRPPG AVAPQLLVAS RGPGAELERA WPAGQPSPLD AFFLPWPARP ALVLVWESGL AEVWGAGVGP GWRPLQSTEL CPGGGARVVA VAALRGRLVW CEERQARAEG PSGSPAAAFS HCVCVRTLEP SGEASTSLGR THVLLHHCPA FGLLASCRQL FLVPTATTWP GVAHVLLIWS PGKGKVMVAA PRLGLSYSKS LNPGRGDTWD FRTLLRGLPG LLSPREPLAV HTWAPTPQGL LLLDFGGTVS LLQSHGGTRA VGTLQEAPVG PWGSAALGTF QGTLACVLGS TLELLDMGSG QLLERKVLST DRVHLLEPPA PGMEDEEELE TRGNLRLLSA LGLFCVGWEA PQGVELPSAK DLVFEEACGY YQRRSLRGAQ LTPEELRHSS TFRAPQALAS ILQGHLPPSA LLTMLRTELR DYRGLEQLKA QLVAGDDEEA GWTELAEQEV ARLLRTELIG DQLAQLNTVF QALPTAAWGA TLRALQLQLD GNGKLRSQAP PDVWKKVLGG ITAGKEPPNG ILPPFELLCQ CLCQLEPRWL PPFVELAQQQ GGPGWGAGGP GLPLYRRALA VLGEEGTRPE ALELELLLSS GRPKAVLQAV GQLVQKEQWD RALDAGLALG PSSPLLRSEI FKLLLAEFAQ HRRLDAHLPL LCRLCPPELA PAELLLLLRT YLPDEVGPPT PFPEPGAEPP LTVGLLKALL EQTGAQGWLS GPVLSPYEDI LWDPSTPPPT PPRDL
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