About 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) is a protein
from Homo sapiens identified by UniProt accession
Q86YW0, 608 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
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| UniProt accession | Q86YW0 |
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| Gene | PLCZ1 |
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| Organism | Homo sapiens |
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| Length | 608 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.67
- glioblastoma multiforme · score 0.23
- endometrial cancer · score 0.23
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.13
- mitochondrial DNA measurement · score 0.12
- Rare genetic female infertility · score 0.08
- age at first sexual intercourse measurement · score 0.06
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- Young syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YW0-F1 | alphafold | PREDICTED | 92.03 | — |
Amino-acid sequence (608 residues)
MEMRWFLSKI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV KQIFKDNDRL KQGRITIEEF RAIYRIITHR EEIIEIFNTY SENRKILLAS NLAQFLTQEQ YAAEMSKAIA FEIIQKYEPI EEVRKAHQMS LEGFTRYMDS RECLLFKNEC RKVYQDMTHP LNDYFISSSH NTYLVSDQLL GPSDLWGYVS ALVKGCRCLE IDCWDGAQNE PVVYHGYTLT SKLLFKTVIQ AIHKYAFMTS DYPVVLSLEN HCSTAQQEVM ADNLQATFGE SLLSDMLDDF PDTLPSPEAL KFKILVKNKK IGTLKETHER KGSDKRGDNQ DKETGVKKLP GVMLFKKKKT RKLKIALALS DLVIYTKAEK FKSFQHSRLY QQFNENNSIG ETQARKLSKL RVHEFIFHTR KFITRIYPKA TRADSSNFNP QEFWNIGCQM VALNFQTPGL PMDLQNGKFL DNGGSGYILK PHFLRESKSY FNPSNIKEGM PITLTIRLIS GIQLPLTHSS SNKGDSLVII EVFGVPNDQM KQQTRVIKKN AFSPRWNETF TFIIHVPELA LIRFVVEGQG LIAGNEFLGQ YTLPLLCMNK GYRRIPLFSR MGESLEPASL FVYVWYVR
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