Trem-like transcript 1 protein (TREML1)

About Trem-like transcript 1 protein

Trem-like transcript 1 protein (TREML1) is a protein from Homo sapiens identified by UniProt accession Q86YW5, 311 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.

Target properties

Protein name	Trem-like transcript 1 protein
UniProt accession	Q86YW5
Gene	TREML1
Organism	Homo sapiens
Length	311 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (126)

Diseases linked to this target (Open Targets).

monocyte count · score 0.12
blood protein measurement · score 0.12
Parkinson disease · score 0.09
Rare hemorrhagic disorder due to a constitutional platelet anomaly · score 0.07
neutrophil count · score 0.07
Glanzmann thrombasthenia 1 · score 0.07
Von Willebrand disease · score 0.06
Bernard-Soulier syndrome · score 0.06
leukocyte count · score 0.06
macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YW5-F1	alphafold	PREDICTED	68.98	—

Amino-acid sequence (311 residues)

MGLTLLLLLL LGLEGQGIVG SLPEVLQAPV GSSILVQCHY RLQDVKAQKV WCRFLPEGCQ PLVSSAVDRR APAGRRTFLT DLGGGLLQVE MVTLQEEDAG EYGCMVDGAR GPQILHRVSL NILPPEEEEE THKIGSLAEN AFSDPAGSAN PLEPSQDEKS IPLIWGAVLL VGLLVAAVVL FAVMAKRKQG NRLGVCGRFL SSRVSGMNPS SVVHHVSDSG PAAELPLDVP HIRLDSPPSF DNTTYTSLPL DSPSGKPSLP APSSLPPLPP KVLVCSKPVT YATVIFPGGN KGGGTSCGPA QNPPNNQTPS S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards