Glycoprotein hormone beta-5 (GPHB5)

About Glycoprotein hormone beta-5

Glycoprotein hormone beta-5 (GPHB5) is a protein from Homo sapiens identified by UniProt accession Q86YW7, 130 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Glycoprotein hormone beta-5
UniProt accession	Q86YW7
Gene	GPHB5
Organism	Homo sapiens
Length	130 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.30
ptosis · score 0.20
body height · score 0.12
adolescent idiopathic scoliosis · score 0.08
insulin resistance · score 0.08
polycystic ovary syndrome · score 0.07
metabolic syndrome · score 0.07
metabolic disease · score 0.02
rosacea · score 0.02
systolic blood pressure · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YW7-F1	alphafold	PREDICTED	87.24	—

Amino-acid sequence (130 residues)

MKLAFLFLGP MALLLLAGYG CVLGASSGNL RTFVGCAVRE FTFLAKKPGC RGLRITTDAC WGRCETWEKP ILEPPYIEAH HRVCTYNETK QVTVKLPNCA PGVDPFYTYP VAIRCDCGAC STATTECETI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards