About Coiled-coil domain-containing protein 125
Coiled-coil domain-containing protein 125 (CCDC125) is a protein
from Homo sapiens identified by UniProt accession
Q86Z20, 511 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 125 |
|---|
| UniProt accession | Q86Z20 |
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| Gene | CCDC125 |
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| Organism | Homo sapiens |
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| Length | 511 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.44
- leukocyte count · score 0.42
- neutrophil percentage of leukocytes · score 0.36
- myeloid white cell count · score 0.36
- lymphocyte percentage of leukocytes · score 0.33
- monocyte percentage of leukocytes · score 0.33
- total blood protein measurement · score 0.29
- granulocyte percentage of myeloid white cells · score 0.27
- granulocyte count · score 0.27
- sum of neutrophil and eosinophil counts · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86Z20-F1 | alphafold | PREDICTED | 67.19 | — |
Amino-acid sequence (511 residues)
MSKVARSSSE SDVQLWETEE DDMTEGDLGY GLGRKPGGIY EIEFSHRSRK RSDGKNFSPP PFPRKGEERN EASFQYSKHK SQQDTFPQVS RISNYRRQSS TVDSNSELSN EELRQCLNET LEEVEMLKTE LEASQRQLRG KEEALKILQS MAILGKATSH TQAVLQKTME QNRSLEKEIN ALQWEIEFDH NRFKNIEESW IQKYDRLNCE NAVLKENLKV KTEEIKMLKS DNAVLNQRYL EALAMLDIKQ QKMAQENMCC DKSGFAEASG LELAVLGACL CHGPGGNPCS CARMAASTRK LLLQLKQELE ILQKSKEEAY VMADAFRIAF EQQLMRKNDQ ALQLTQMDKM HKKATKWMNW KHLKEDGFPS PRSKKTFGQR LLGMLPSENS SKRMEDQDSP QEVLKMLIDL LNDKEEALAH QRKVSYMLAR ALEDKDTASN ENKEKNPIKE NFPFNNPWRK TSEFSVLGDP IHSSVCILNS VGCICSIQHS QIDPNYRTLK RSHSLPSSII F
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