Interferon lambda receptor 1 (IFNLR1)

About Interferon lambda receptor 1

Interferon lambda receptor 1 (IFNLR1) is a protein from Homo sapiens identified by UniProt accession Q8IU57, 520 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Interferon lambda receptor 1
UniProt accession	Q8IU57
Gene	IFNLR1
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

hepatitis C virus infection · score 0.39
psoriasis · score 0.37
type 2 diabetes mellitus · score 0.32
COVID-19 · score 0.30
hepatitis D virus infection · score 0.29
chronic hepatitis C virus infection · score 0.28
ankylosing spondylitis · score 0.25
Crohn's disease · score 0.25
ulcerative colitis · score 0.25
sclerosing cholangitis · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IU57-F1	alphafold	PREDICTED	64.23	—

Amino-acid sequence (520 residues)

MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP QDVTYFVAYQ SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV RTVSPSSKSP WVESEYLDYL FEVEPAPPVL VLTQTEEILS ANATYQLPPC MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ PVQITLQPAA SEHHCLSART IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL VIAAGGVIWK TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL GQEHQAPGHS EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR AGSSGYLAEK GPGQGPGGDG HQESLPPPEF SKDSGFLEEL PEDNLSSWAT WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP EEEEEARESE IEDSDAGSWG AESTQRTEDR GRTLGHYMAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards