About Transmembrane channel-like protein 8
Transmembrane channel-like protein 8 (TMC8) is a protein
from Homo sapiens identified by UniProt accession
Q8IU68, 726 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | Transmembrane channel-like protein 8 |
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| UniProt accession | Q8IU68 |
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| Gene | TMC8 |
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| Organism | Homo sapiens |
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| Length | 726 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (99)
Diseases linked to this target (Open Targets).
- epidermodysplasia verruciformis · score 0.75
- HbA1c measurement · score 0.47
- mean corpuscular volume · score 0.32
- mean corpuscular hemoglobin concentration · score 0.32
- mean corpuscular hemoglobin · score 0.32
- erythrocyte count · score 0.30
- hemolysis · score 0.23
- Red cell distribution width · score 0.22
- genetic disorder · score 0.19
- bilirubin measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IU68-F1 | alphafold | PREDICTED | 75.94 | — |
Amino-acid sequence (726 residues)
MLLPRSVSSE RAPGVPEPEE LWEAEMERLR GSGTPVRGLP YAMMDKRLIW QLREPAGVQT LRWQRWQRRR QTVERRLREA AQRLARGLGL WEGALYEIGG LFGTGIRSYF TFLRFLLLLN LLSLLLTASF VLLPLVWLRP PDPGPTLNLT LQCPGSRQSP PGVLRFHNQL WHVLTGRAFT NTYLFYGAYR VGPESSSVYS IRLAYLLSPL ACLLLCFCGT LRRMVKGLPQ KTLLGQGYQA PLSAKVFSSW DFCIRVQEAA TIKKHEISNE FKVELEEGRR FQLMQQQTRA QTACRLLSYL RVNVLNGLLV VGAISAIFWA TKYSQDNKEE SLFLLLQYLP PGVIALVNFL GPLLFTFLVQ LENYPPNTEV NLTLIWCVVL KLASLGMFSV SLGQTILCIG RDKSSCESYG YNVCDYQCWE NSVGEELYKL SIFNFLLTVA FAFLVTLPRR LLVDRFSGRF WAWLEREEFL VPKNVLDIVA GQTVTWMGLF YCPLLPLLNS VFLFLTFYIK KYTLLKNSRA SSRPFRASSS TFFFQLVLLL GLLLAAVPLG YVVSSIHSSW DCGLFTNYSA PWQVVPELVA LGLPPIGQRA LHYLGSHAFS FPLLIMLSLV LTVCVSQTQA NARAIHRLRK QLVWQVQEKW HLVEDLSRLL PEPGPSDSPG PKYPASQASR PQSFCPGCPC PGSPGHQAPR PGPSVVDAAG LRSPCPGQHG APASARRFRF PSGAEL
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