About Interferon regulatory factor 2-binding protein 1
Interferon regulatory factor 2-binding protein 1 (IRF2BP1) is a protein
from Homo sapiens identified by UniProt accession
Q8IU81, 584 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Interferon regulatory factor 2-binding protein 1 |
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| UniProt accession | Q8IU81 |
|---|
| Gene | IRF2BP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.28
- high density lipoprotein cholesterol measurement · score 0.27
- mean corpuscular hemoglobin concentration · score 0.26
- apolipoprotein A 1 measurement · score 0.24
- total cholesterol measurement · score 0.22
- low density lipoprotein cholesterol measurement · score 0.22
- C-reactive protein measurement · score 0.21
- bilirubin measurement · score 0.19
- mean corpuscular hemoglobin · score 0.17
- mean corpuscular volume · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IU81-F1 | alphafold | PREDICTED | 64.46 | — |
Amino-acid sequence (584 residues)
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP
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