Ceramide synthase 3 (CERS3)

About Ceramide synthase 3

Ceramide synthase 3 (CERS3) is a protein from Homo sapiens identified by UniProt accession Q8IU89, 383 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Ceramide synthase 3
UniProt accession	Q8IU89
Gene	CERS3
Organism	Homo sapiens
Length	383 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

congenital non-bullous ichthyosiform erythroderma · score 0.59
autosomal recessive congenital ichthyosis · score 0.38
lamellar ichthyosis · score 0.35
Abnormality of the skin · score 0.33
cotinine glucuronidation measurement · score 0.33
body mass index · score 0.26
genetic disorder · score 0.19
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IU89-F1	alphafold	PREDICTED	87.32	—

Amino-acid sequence (383 residues)

MFWTFKEWFW LERFWLPPTI KWSDLEDHDG LVFVKPSHLY VTIPYAFLLL IIRRVFEKFV ASPLAKSFGI KETVRKVTPN TVLENFFKHS TRQPLQTDIY GLAKKCNLTE RQVERWFRSR RNQERPSRLK KFQEACWRFA FYLMITVAGI AFLYDKPWLY DLWEVWNGYP KQPLLPSQYW YYILEMSFYW SLLFRLGFDV KRKDFLAHII HHLAAISLMS FSWCANYIRS GTLVMIVHDV ADIWLESAKM FSYAGWTQTC NTLFFIFSTI FFISRLIVFP FWILYCTLIL PMYHLEPFFS YIFLNLQLMI LQVLHLYWGY YILKMLNRCI FMKSIQDVRS DDEDYEEEEE EEEEEATKGK EMDCLKNGLR AERHLIPNGQ HGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards