Calcium homeostasis modulator protein 1 (CALHM1)

About Calcium homeostasis modulator protein 1

Calcium homeostasis modulator protein 1 (CALHM1) is a protein from Homo sapiens identified by UniProt accession Q8IU99, 346 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Calcium homeostasis modulator protein 1
UniProt accession	Q8IU99
Gene	CALHM1
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

lymphocyte percentage of leukocytes · score 0.12
atrial fibrillation · score 0.08
diastolic blood pressure · score 0.07
white matter hyperintensity measurement · score 0.07
self reported educational attainment · score 0.06
atrial flutter · score 0.06
cardiac arrhythmia · score 0.06
cardiac edema · score 0.05
Pallister-Hall syndrome · score 0.04
central nervous system cancer · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IU99-F1	alphafold	PREDICTED	74.92	—

Amino-acid sequence (346 residues)

MMDKFRMIFQ FLQSNQESFM NGICGIMALA SAQMYSAFDF NCPCLPGYNA AYSAGILLAP PLVLFLLGLV MNNNVSMLAE EWKRPLGRRA KDPAVLRYMF CSMAQRALIA PVVWVAVTLL DGKCFLCAFC TAVPVSALGN GSLAPGLPAP ELARLLARVP CPEIYDGDWL LAREVAVRYL RCISQALGWS FVLLTTLLAF VVRSVRPCFT QAAFLKSKYW SHYIDIERKL FDETCTEHAK AFAKVCIQQF FEAMNHDLEL GHTHGTLATA PASAAAPTTP DGAEEEREKL RGITDQGTMN RLLTSWHKCK PPLRLGQEEP PLMGNGWAGG GPRPPRKEVA TYFSKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards