About WAP four-disulfide core domain protein 3
WAP four-disulfide core domain protein 3 (WFDC3) is a protein
from Homo sapiens identified by UniProt accession
Q8IUB2, 231 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | WAP four-disulfide core domain protein 3 |
|---|
| UniProt accession | Q8IUB2 |
|---|
| Gene | WFDC3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 231 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- platelet count · score 0.27
- mean platelet volume · score 0.26
- body height · score 0.21
- PHF-tau measurement · score 0.14
- pancreatic adenocarcinoma · score 0.07
- neoplasm · score 0.06
- sebaceous of Jadassohn nevus · score 0.04
- non-small cell lung carcinoma · score 0.03
- psoriasis · score 0.02
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IUB2-F1 | alphafold | PREDICTED | 74.21 | — |
Amino-acid sequence (231 residues)
MMLSCLFLLK ALLALGSLES WITAGEHAKE GECPPHKNPC KELCQGDELC PAEQKCCTTG CGRICRDIPK GRKRDCPRVI RKQSCLKRCI TDETCPGVKK CCTLGCNKSC VVPISKQKLA EFGGECPADP LPCEELCDGD ASCPQGHKCC STGCGRTCLG DIEGGRGGDC PKVLVGLCIV GCVMDENCQA GEKCCKSGCG RFCVPPVLPP KLTMNPNWTV RSDSELEIPV P
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