Cytokine receptor-like factor 3 (CRLF3)

About Cytokine receptor-like factor 3

Cytokine receptor-like factor 3 (CRLF3) is a protein from Homo sapiens identified by UniProt accession Q8IUI8, 442 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Cytokine receptor-like factor 3
UniProt accession	Q8IUI8
Gene	CRLF3
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
platelet component distribution width · score 0.37
lymphocyte count · score 0.34
mean platelet volume · score 0.34
Red cell distribution width · score 0.28
mean corpuscular volume · score 0.25
forced expiratory volume · score 0.24
mean corpuscular hemoglobin · score 0.24
body height · score 0.24
lymphocyte percentage of leukocytes · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUI8-F1	alphafold	PREDICTED	89.67	—

Amino-acid sequence (442 residues)

MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ TRDVLKQHFN DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE HGVNTAEDLV REGEIAMLGG VGEENEKLWS FTKKASHIQL DSLPEVPLLV DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID PNVDYQFRVC ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF KLRVTISSNN REVVFDWLLD QSCGSLYFGC SFFYPGWKVL VF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards