About Neuronal PAS domain-containing protein 4
Neuronal PAS domain-containing protein 4 (NPAS4) is a protein
from Homo sapiens identified by UniProt accession
Q8IUM7, 802 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | Neuronal PAS domain-containing protein 4 |
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| UniProt accession | Q8IUM7 |
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| Gene | NPAS4 |
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| Organism | Homo sapiens |
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| Length | 802 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (107)
Diseases linked to this target (Open Targets).
- body height · score 0.15
- vital capacity · score 0.13
- Microcephaly · score 0.12
- alcohol consumption measurement · score 0.11
- attention deficit hyperactivity disorder · score 0.10
- risk-taking behaviour · score 0.09
- antisocial behaviour measurement · score 0.08
- substance abuse · score 0.08
- fat body mass · score 0.08
- BMI-adjusted waist-hip ratio · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IUM7-F1 | alphafold | PREDICTED | 56.31 | — |
Amino-acid sequence (802 residues)
MYRSTKGASK ARRDQINAEI RNLKELLPLA EADKVRLSYL HIMSLACIYT RKGVFFAGGT PLAGPTGLLS AQELEDIVAA LPGFLLVFTA EGKLLYLSES VSEHLGHSMV DLVAQGDSIY DIIDPADHLT VRQQLTLPSA LDTDRLFRCR FNTSKSLRRQ SAGNKLVLIR GRFHAHPPGA YWAGNPVFTA FCAPLEPRPR PGPGPGPGPA SLFLAMFQSR HAKDLALLDI SESVLIYLGF ERSELLCKSW YGLLHPEDLA HASAQHYRLL AESGDIQAEM VVRLQAKTGG WAWIYCLLYS EGPEGPITAN NYPISDMEAW SLRQQLNSED TQAAYVLGTP TMLPSFPENI LSQEECSSTN PLFTAALGAP RSTSFPSAPE LSVVSASEEL PRPSKELDFS YLTFPSGPEP SLQAELSKDL VCTPPYTPHQ PGGCAFLFSL HEPFQTHLPT PSSTLQEQLT PSTATFSDQL TPSSATFPDP LTSPLQGQLT ETSVRSYEDQ LTPCTSTFPD QLLPSTATFP EPLGSPAHEQ LTPPSTAFQA HLDSPSQTFP EQLSPNPTKT YFAQEGCSFL YEKLPPSPSS PGNGDCTLLA LAQLRGPLSV DVPLVPEGLL TPEASPVKQS FFHYSEKEQN EIDRLIQQIS QLAQGMDRPF SAEAGTGGLE PLGGLEPLDS NLSLSGAGPP VLSLDLKPWK CQELDFLADP DNMFLEETPV EDIFMDLSTP DPSEEWGSGD PEAEGPGGAP SPCNNLSPED HSFLEDLATY ETAFETGVSA FPYDGFTDEL HQLQSQVQDS FHEDGSGGEP TF
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