About Complex I assembly factor TMEM126B, mitochondrial
Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) is a protein
from Homo sapiens identified by UniProt accession
Q8IUX1, 230 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Complex I assembly factor TMEM126B, mitochondrial |
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| UniProt accession | Q8IUX1 |
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| Gene | TMEM126B |
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| Organism | Homo sapiens |
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| Length | 230 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- mitochondrial complex I deficiency · score 0.67
- neurodegenerative disease · score 0.51
- mitochondrial disease · score 0.51
- genetic disorder · score 0.18
- fat body mass · score 0.08
- waist circumference · score 0.06
- body fat percentage · score 0.05
- mathematical ability · score 0.04
- response to TNF antagonist · score 0.03
- joint damage measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IUX1-F1 | alphafold | PREDICTED | 81.42 | — |
Amino-acid sequence (230 residues)
MVVFGYEAGT KPRDSGVVPV GTEEAPKVFK MAASMHGQPS PSLEDAKLRR PMVIEIIEKN FDYLRKEMTQ NIYQMATFGT TAGFSGIFSN FLFRRCFKVK HDALKTYASL ATLPFLSTVV TDKLFVIDAL YSDNISKENC VFRSSLIGIV CGVFYPSSLA FTKNGRLATK YHTVPLPPKG RVLIHWMTLC QTQMKLMAIP LVFQIMFGIL NGLYHYAVFE ETLEKTIHEE
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