DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F)

About DNA dC->dU-editing enzyme APOBEC-3F

DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F) is a protein from Homo sapiens identified by UniProt accession Q8IUX4, 373 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	DNA dC->dU-editing enzyme APOBEC-3F
UniProt accession	Q8IUX4
Gene	APOBEC3F
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

immune deficiency, familial variable · score 0.08
immunodeficiency 35 · score 0.07
Chronic mucocutaneous candidosis · score 0.07
hyper-IgM syndrome type 2 · score 0.07
isolated agammaglobulinemia · score 0.07
immunodeficiency, common variable, 4 · score 0.06
hyper-IgM syndrome type 3 · score 0.06
IgAD1 · score 0.06
selective IgA deficiency disease · score 0.06
severe combined immunodeficiency due to CARD11 deficiency · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUX4-F1	alphafold	PREDICTED	89.19	—

Amino-acid sequence (373 residues)

MKPHFRNTVE RMYRDTFSYN FYNRPILSRR NTVWLCYEVK TKGPSRPRLD AKIFRGQVYS QPEHHAEMCF LSWFCGNQLP AYKCFQITWF VSWTPCPDCV AKLAEFLAEH PNVTLTISAA RLYYYWERDY RRALCRLSQA GARVKIMDDE EFAYCWENFV YSEGQPFMPW YKFDDNYAFL HRTLKEILRN PMEAMYPHIF YFHFKNLRKA YGRNESWLCF TMEVVKHHSP VSWKRGVFRN QVDPETHCHA ERCFLSWFCD DILSPNTNYE VTWYTSWSPC PECAGEVAEF LARHSNVNLT IFTARLYYFW DTDYQEGLRS LSQEGASVEI MGYKDFKYCW ENFVYNDDEP FKPWKGLKYN FLFLDSKLQE ILE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards