Epidermal growth factor-like protein 6 (EGFL6)

About Epidermal growth factor-like protein 6

Epidermal growth factor-like protein 6 (EGFL6) is a protein from Homo sapiens identified by UniProt accession Q8IUX8, 553 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Epidermal growth factor-like protein 6
UniProt accession	Q8IUX8
Gene	EGFL6
Organism	Homo sapiens
Length	553 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
exstrophy-epispadias complex · score 0.12
neoplasm · score 0.09
cancer · score 0.09
colorectal carcinoma · score 0.07
oral squamous cell carcinoma · score 0.06
Crohn's disease · score 0.05
benign meningioma · score 0.05
ulcerative colitis · score 0.04
colorectal adenocarcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUX8-F1	alphafold	PREDICTED	65.83	—

Amino-acid sequence (553 residues)

MPLPWSLALP LLLSWVAGGF GNAASARHHG LLASARQPGV CHYGTKLACC YGWRRNSKGV CEATCEPGCK FGECVGPNKC RCFPGYTGKT CSQDVNECGM KPRPCQHRCV NTHGSYKCFC LSGHMLMPDA TCVNSRTCAM INCQYSCEDT EEGPQCLCPS SGLRLAPNGR DCLDIDECAS GKVICPYNRR CVNTFGSYYC KCHIGFELQY ISGRYDCIDI NECTMDSHTC SHHANCFNTQ GSFKCKCKQG YKGNGLRCSA IPENSVKEVL RAPGTIKDRI KKLLAHKNSM KKKAKIKNVT PEPTRTPTPK VNLQPFNYEE IVSRGGNSHG GKKGNEEKMK EGLEDEKREE KALKNDIEER SLRGDVFFPK VNEAGEFGLI LVQRKALTSK LEHKDLNISV DCSFNHGICD WKQDREDDFD WNPADRDNAI GFYMAVPALA GHKKDIGRLK LLLPDLQPQS NFCLLFDYRL AGDKVGKLRV FVKNSNNALA WEKTTSEDEK WKTGKIQLYQ GTDATKSIIF EAERGKGKTG EIAVDGVLLV SGLCPDSLLS VDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards