5'-3' exonuclease PLD3 (PLD3)

About 5'-3' exonuclease PLD3

5'-3' exonuclease PLD3 (PLD3) is a protein from Homo sapiens identified by UniProt accession Q8IV08, 490 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	5'-3' exonuclease PLD3
UniProt accession	Q8IV08
Gene	PLD3
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

Autosomal dominant cerebellar ataxia type 1 · score 0.48
breast adenocarcinoma · score 0.25
endometrial cancer · score 0.23
head and neck squamous cell carcinoma · score 0.21
neurodegenerative disease · score 0.17
Alzheimer disease · score 0.11
prostate cancer · score 0.11
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
blood protein measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IV08-F1	alphafold	PREDICTED	91.18	—

Amino-acid sequence (490 residues)

MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVN VRIAVSKPSG PQPQADLQAL LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL ARDLTKIFEA YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC PSGRTPDLKA LLNVVDNARS FIYVAVMNYL PTLEFSHPHR FWPAIDDGLR RATYERGVKV RLLISCWGHS EPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADEAQARIP YARVNHNKYM VTERATYIGT SNWSGNYFTE TAGTSLLVTQ NGRGGLRSQL EAIFLRDWDS PYSHDLDTSA DSVGNACRLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards