Purine nucleoside phosphorylase LACC1 (LACC1)

About Purine nucleoside phosphorylase LACC1

Purine nucleoside phosphorylase LACC1 (LACC1) is a protein from Homo sapiens identified by UniProt accession Q8IV20, 430 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Purine nucleoside phosphorylase LACC1
UniProt accession	Q8IV20
Gene	LACC1
Organism	Homo sapiens
Length	430 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

juvenile arthritis due to defect in LACC1 · score 0.64
Crohn's disease · score 0.45
leprosy · score 0.44
psoriasis · score 0.39
inflammatory bowel disease · score 0.38
systemic juvenile idiopathic arthritis · score 0.37
asthma · score 0.37
Behcet's syndrome · score 0.30
ulcerative colitis · score 0.30
ankylosing spondylitis · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IV20-F1	alphafold	PREDICTED	88.72	—

Amino-acid sequence (430 residues)

MAEAVLIDLF GLKLNSQKNC HQTLLKTLNA VQYHHAAKAK FLCIMCCSNI SYERDGEQDN CEIETSNGLS ALLEEFEIVS CPSMAATLYT IKQKIDEKNL SSIKVIVPRH RKTLMKAFID QLFTDVYNFE FEDLQVTFRG GLFKQSIEIN VITAQELRGI QNEIETFLRS LPALRGKLTI ITSSLIPDIF IHGFTTRTGG ISYIPTLSSF NLFSSSKRRD PKVVVQENLR RLANAAGFNV EKFYRIKTHH SNDIWIMGRK EPDSYDGITT NQRGVTIAAL GADCIPIVFA DPVKKACGVA HAGWKGTLLG VAMATVNAMI AEYGCSLEDI VVVLGPSVGP CCFTLPRESA EAFHNLHPAC VQLFDSPNPC IDIRKATRIL LEQGGILPQN IQDQNQDLNL CTSCHPDKFF SHVRDGLNFG TQIGFISIKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards