Transmembrane protein 139 (TMEM139)

About Transmembrane protein 139

Transmembrane protein 139 (TMEM139) is a protein from Homo sapiens identified by UniProt accession Q8IV31, 216 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Transmembrane protein 139
UniProt accession	Q8IV31
Gene	TMEM139
Organism	Homo sapiens
Length	216 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.12
non-small cell lung carcinoma · score 0.08
Barrett's esophagus · score 0.05
neoplasm · score 0.02
cancer · score 0.01
ovarian carcinoma · score 0.01
psoriasis · score 0.01
Kidney Oncocytoma · score 0.01
COVID-19 · score 0.01
papillary thyroid carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IV31-F1	alphafold	PREDICTED	64.48	—

Amino-acid sequence (216 residues)

MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG HPDDDSVFYE DNWAPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards