About Cilia- and flagella-associated protein 337
Cilia- and flagella-associated protein 337 (CFAP337) is a protein
from Homo sapiens identified by UniProt accession
Q8IV35, 1049 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 337 |
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| UniProt accession | Q8IV35 |
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| Gene | CFAP337 |
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| Organism | Homo sapiens |
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| Length | 1049 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.41
- electrocardiography · score 0.31
- platelet count · score 0.25
- diet measurement · score 0.23
- breast milk measurement · score 0.22
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- worry measurement · score 0.06
- actinic keratosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IV35-F1 | alphafold | PREDICTED | 71.88 | — |
Amino-acid sequence (1049 residues)
MSCQKAVLEL NIGSQLGPKS PERTEGVTAF EDYGTGLLEN QLSVGDFVKI QKAFESPQPR KIICMSREDF TQKMTEIVGW GTKEEYGELF DKVDVAQDGF INWDKLTSFI LLELYEQDER AKATVVPQWK DLEFLPVKHK DTIQKVIFLK NSSHYLTISK EGLLAIWGEH LKLQETFPIT SDATKLKHLW VTSLVSLENV NKIAVAFTSK EVCFYDLLSK EEFACQYKLQ GLKGTPICMD YWYDPLDANE SILSFGDITG KVQAIAFTAA LISLFERPAS ACEDGEATMT INWAELLSGC HKCCHILEHK LHQGDWVRQV TYNASLDAII SSTTSNTNSV VMAWREKSKK RLNMTSFNIA QGIHAFDYHS RLNLIATAGI NNKVCLWNPY VVSKPVGVLW GHSASVIAVQ FFVERKQLFS FSKDKVLRLW DIQHQLSIQR IACSFPKSQD FRCLFHFDEA HGRLFISFNN QLALLAMKSE ASKRVKSHEK AVTCVLYNSI LKQVISSDTG STVSFWMIDT GQKIKQFTGC HGNAEISTMA LDANETRLLT GSTDGTVKIW DFNGYCHHTL NVGQDGAVDI SQILILKKKI LVTGWERYDY ASWKTIGRAI TVFRPQNFNQ FFIQPEEWKG GIQHHDDILC AAFLPPQTLV TGSYDGEIVL WNNSTENAHH VLHPDYQRLL KSKLDTKPQK LLSAGRSQPS HPMADHSTTG VRNFEIDTEG KNAVMRLCFL KARKNTAVTG GANLVSCGGS GYVRFWDIYK KQLLAEFLAH SGVGSIIMST DKMNRYLTTG DLDGWLKIWN IEEYCLNSSK NKITKAPTLI RSFQPHEDRI SSLEMCEPGG QLLIISSSAD CSICVTGVCN APVWIFGQAK HWHIENCLFL PKRDTNLVES EIQKEISLFS KEESCLDPTE HSLLNKKNKD DSTYNVRPSE DINLDIKYKE RSTCMKETQK PYYGEVIKKS FSTFRSLNIG ALEELPEVNK PAFLLDPEKY FRKEPEEERP QILEAPSLFK TLKAVFDEKN LFPKEILHHE RKAKQLCQEK SCEVKKNKK
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