About Ankyrin repeat and MYND domain-containing protein 2
Ankyrin repeat and MYND domain-containing protein 2 (ANKMY2) is a protein
from Homo sapiens identified by UniProt accession
Q8IV38, 441 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Ankyrin repeat and MYND domain-containing protein 2 |
|---|
| UniProt accession | Q8IV38 |
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| Gene | ANKMY2 |
|---|
| Organism | Homo sapiens |
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| Length | 441 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.30
- neurodegenerative disease · score 0.22
- reticulocyte count · score 0.16
- reticulocyte measurement · score 0.14
- Immature Reticulocyte Fraction Measurement · score 0.13
- Red cell distribution width · score 0.13
- mean platelet volume · score 0.12
- mean corpuscular hemoglobin concentration · score 0.11
- pathological myopia · score 0.11
- Myopia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IV38-F1 | alphafold | PREDICTED | 86.47 | — |
Amino-acid sequence (441 residues)
MVHIKKGELT QEEKELLEVI GKGTVQEAGT LLSSKNVRVN CLDENGMTPL MHAAYKGKLD MCKLLLRHGA DVNCHQHEHG YTALMFAALS GNKDITWVML EAGAETDVVN SVGRTAAQMA AFVGQHDCVT IINNFFPRER LDYYTKPQGL DKEPKLPPKL AGPLHKIITT TNLHPVKIVM LVNENPLLTE EAALNKCYRV MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCINFLKDGE NKLDTLIKSL LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW FTHKKICKNL KDIYEKQQLE AAKEKRQEEN HGKLDVNSNC VNEEQPEAEV GISQKDSNPE DSGEGKKESL ESEAELEGLQ DAPAGPQVSE E
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