L-seryl-tRNA(Sec) kinase (PSTK)

About L-seryl-tRNA(Sec) kinase

L-seryl-tRNA(Sec) kinase (PSTK) is a protein from Homo sapiens identified by UniProt accession Q8IV42, 348 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	L-seryl-tRNA(Sec) kinase
UniProt accession	Q8IV42
Gene	PSTK
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
Red cell distribution width · score 0.08
hepatocellular carcinoma · score 0.08
mean corpuscular hemoglobin concentration · score 0.07
low density lipoprotein cholesterol measurement · score 0.07
reticulocyte count · score 0.06
mean corpuscular volume · score 0.06
apolipoprotein B measurement · score 0.06
high density lipoprotein cholesterol measurement · score 0.05
alcohol drinking · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IV42-F1	alphafold	PREDICTED	76.46	—

Amino-acid sequence (348 residues)

MKTAENIRGT GSDGPRKRGL CVLCGLPAAG KSTFARALAH RLQQEQGWAI GVVAYDDVMP DAFLAGARAR PAPSQWKLLR QELLKYLEYF LMAVINGCQM SVPPNRTEAM WEDFITCLKD QDLIFSAAFE AQSCYLLTKT AVSRPLFLVL DDNFYYQSMR YEVYQLARKY SLGFCQLFLD CPLETCLQRN GQRPQALPPE TIHLMGRKLE KPNPEKNAWE HNSLTIPSPA CASEASLEVT DLLLTALENP VKYAEDNMEQ KDTDRIICST NILHKTDQTL RRIVSQTMKE AKGNQEAFSE MTFKQRWVRA NHAAIWRIIL GNEHIKCRSA KVGWLQCCRI EKRPLSTG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards