About UNC5C-like protein
UNC5C-like protein (UNC5CL) is a protein
from Homo sapiens identified by UniProt accession
Q8IV45, 518 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | UNC5C-like protein |
|---|
| UniProt accession | Q8IV45 |
|---|
| Gene | UNC5CL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 518 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.31
- serum gamma-glutamyl transferase measurement · score 0.30
- creatinine measurement · score 0.30
- urate measurement · score 0.26
- C-C motif chemokine 20 measurement · score 0.24
- uric acid measurement · score 0.16
- esophageal carcinoma · score 0.14
- sex hormone-binding globulin measurement · score 0.13
- gastric carcinoma · score 0.08
- type 2 diabetes mellitus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IV45-F1 | alphafold | PREDICTED | 79.75 | — |
Amino-acid sequence (518 residues)
MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE EPVSQPTPQL ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL LVFSAREVDH RGGCLMLQDT GISLLIPPGA VAVGRQERVS LILVWDLSDA PSLSQAQGLV SPVVACGPHG ASFLKPCTLT FKHCAEQPSH ARTYSSNTTL LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG REARKWLQLA VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA ADENEDCSAL TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS QPPPCNRLPP ELFEQLRMLL EPNSITGNDW RRLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTVMER LDCASAIQNY LSGTHGGSPG PERGGARDNQ GLELDEKL
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