3'-5' exoribonuclease 1 (ERI1)

About 3'-5' exoribonuclease 1

3'-5' exoribonuclease 1 (ERI1) is a protein from Homo sapiens identified by UniProt accession Q8IV48, 349 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	3'-5' exoribonuclease 1
UniProt accession	Q8IV48
Gene	ERI1
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
mean corpuscular volume · score 0.46
spondyloepimetaphyseal dysplasia, Guo-Campeau type · score 0.45
platelet component distribution width · score 0.45
mean corpuscular hemoglobin · score 0.42
mean corpuscular hemoglobin concentration · score 0.42
platelet count · score 0.38
Intellectual disability · score 0.37
Spondyloepimetaphyseal dysplasia · score 0.37
spondyloepimetaphyseal dysplasia · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IV48-F1	alphafold	PREDICTED	85.23	—

Amino-acid sequence (349 residues)

MEDPQSKEPA GEAVALALLE SPRPEGGEEP PRPSPEETQQ CKFDGQETKG SKFITSSASD FSDPVYKEIA ITNGCINRMS KEELRAKLSE FKLETRGVKD VLKKRLKNYY KKQKLMLKES NFADSYYDYI CIIDFEATCE EGNPPEFVHE IIEFPVVLLN THTLEIEDTF QQYVRPEINT QLSDFCISLT GITQDQVDRA DTFPQVLKKV IDWMKLKELG TKYKYSLLTD GSWDMSKFLN IQCQLSRLKY PPFAKKWINI RKSYGNFYKV PRSQTKLTIM LEKLGMDYDG RPHCGLDDSK NIARIAVRML QDGCELRINE KMHAGQLMSV SSSLPIEGTP PPQMPHFRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards