About Ras guanyl-releasing protein 3
Ras guanyl-releasing protein 3 (RASGRP3) is a protein
from Homo sapiens identified by UniProt accession
Q8IV61, 690 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Ras guanyl-releasing protein 3 |
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| UniProt accession | Q8IV61 |
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| Gene | RASGRP3 |
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| Organism | Homo sapiens |
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| Length | 690 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (196)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.45
- systemic lupus erythematosus · score 0.40
- brain volume measurement · score 0.36
- neuroimaging measurement · score 0.36
- white matter microstructure measurement · score 0.36
- lip and oral cavity carcinoma · score 0.34
- body height · score 0.33
- albumin:globulin ratio measurement · score 0.32
- serum non-albumin protein measurement · score 0.32
- FEV/FVC ratio · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IV61-F1 | alphafold | PREDICTED | 69.77 | — |
Amino-acid sequence (690 residues)
MGSSGLGKAA TLDELLCTCI EMFDDNGELD NSYLPRIVLL MHRWYLSSTE LAEKLLCMYR NATGESCNEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE EFREVASQLG YEKHVSLIDI SSIPSYDWMR RVTQRKKVSK KGKACLLFDH LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG ISKWVQLMVL SKPTPQQRAE VITKFINVAK KLLQLKNFNT LMAVVGGLSH SSISRLKETH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP ILGVHLKDLI AVHVIFPDWT EENKVNIVKM HQLSVTLSEL VSLQNASHHL EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV PLEWALGVMP KPDPTVINKH IRKLVESVFR NYDHDHDGYI SQEDFESIAA NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR AKSQLHCKMG PGFIHNFQEM TYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL VLACRRFARA PSLSSGHGSL PGSPSLPPAQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK ISVRLQRATT SQATQTEPVW SEAGWGDSGS HTFPKMKSKF HDKAAKDKGF AKWENEKPRV HAGVDVVDRG TEFELDQDEG EETRQDGEDG
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