About Cyclic nucleotide-gated channel alpha-4
Cyclic nucleotide-gated channel alpha-4 (CNGA4) is a protein
from Homo sapiens identified by UniProt accession
Q8IV77, 575 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Cyclic nucleotide-gated channel alpha-4 |
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| UniProt accession | Q8IV77 |
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| Gene | CNGA4 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- mathematical ability · score 0.17
- gastroesophageal reflux disease · score 0.15
- duodenal ulcer · score 0.14
- peptic ulcer disease · score 0.12
- Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement · score 0.10
- Leber congenital amaurosis 10 · score 0.05
- body mass index · score 0.04
- Abnormality of the ear · score 0.04
- Absent thumb - short stature - immunodeficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IV77-F1 | alphafold | PREDICTED | 83.51 | — |
Amino-acid sequence (575 residues)
MSQDTKVKTT ESSPPAPSKA RKLLPVLDPS GDYYYWWLNT MVFPVMYNLI ILVCRACFPD LQHGYLVAWL VLDYTSDLLY LLDMVVRFHT GFLEQGILVV DKGRISSRYV RTWSFFLDLA SLMPTDVVYV RLGPHTPTLR LNRFLRAPRL FEAFDRTETR TAYPNAFRIA KLMLYIFVVI HWNSCLYFAL SRYLGFGRDA WVYPDPAQPG FERLRRQYLY SFYFSTLILT TVGDTPPPAR EEEYLFMVGD FLLAVMGFAT IMGSMSSVIY NMNTADAAFY PDHALVKKYM KLQHVNRKLE RRVIDWYQHL QINKKMTNEV AILQHLPERL RAEVAVSVHL STLSRVQIFQ NCEASLLEEL VLKLQPQTYS PGEYVCRKGD IGQEMYIIRE GQLAVVADDG ITQYAVLGAG LYFGEISIIN IKGNMSGNRR TANIKSLGYS DLFCLSKEDL REVLSEYPQA QTIMEEKGRE ILLKMNKLDV NAEAAEIALQ EATESRLRGL DQQLDDLQTK FARLLAELES SALKIAYRIE RLEWQTREWP MPEDLAEADD EGEPEEGTSK DEEGRASQEG PPGPE
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