About Sodium/hydrogen exchanger 9
Sodium/hydrogen exchanger 9 (SLC9A9) is a protein
from Homo sapiens identified by UniProt accession
Q8IVB4, 645 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Sodium/hydrogen exchanger 9 |
|---|
| UniProt accession | Q8IVB4 |
|---|
| Gene | SLC9A9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 645 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- autism · score 0.49
- mean platelet volume · score 0.40
- cortical surface area measurement · score 0.40
- gut microbiome measurement · score 0.39
- PHF-tau measurement · score 0.37
- colorectal cancer · score 0.33
- brain measurement · score 0.32
- viral load · score 0.31
- diabetes mellitus · score 0.25
- cutaneous melanoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVB4-F1 | alphafold | PREDICTED | 73.49 | — |
Amino-acid sequence (645 residues)
MERQSRVMSE KDEYQFQHQG AVELLVFNFL LILTILTIWL FKNHRFRFLH ETGGAMVYGL IMGLILRYAT APTDIESGTV YDCVKLTFSP STLLVNITDQ VYEYKYKREI SQHNINPHQG NAILEKMTFD PEIFFNVLLP PIIFHAGYSL KKRHFFQNLG SILTYAFLGT AISCIVIGLI MYGFVKAMIH AGQLKNGDFH FTDCLFFGSL MSATDPVTVL AIFHELHVDP DLYTLLFGES VLNDAVAIVL TYSISIYSPK ENPNAFDAAA FFQSVGNFLG IFAGSFAMGS AYAIITALLT KFTKLCEFPM LETGLFFLLS WSAFLSAEAA GLTGIVAVLF CGVTQAHYTY NNLSSDSKIR TKQLFEFMNF LAENVIFCYM GLALFTFQNH IFNALFILGA FLAIFVARAC NIYPLSFLLN LGRKQKIPWN FQHMMMFSGL RGAIAFALAI RNTESQPKQM MFTTTLLLVF FTVWVFGGGT TPMLTWLQIR VGVDLDENLK EDPSSQHQEA NNLDKNMTKA ESARLFRMWY SFDHKYLKPI LTHSGPPLTT TLPEWCGPIS RLLTSPQAYG EQLKEDDVEC IVNQDELAIN YQEQASSPCS PPARLGLDQK ASPQTPGKEN IYEGDLGLGG YELKLEQTLG QSQLN
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