NudC domain-containing protein 3 (NUDCD3)

About NudC domain-containing protein 3

NudC domain-containing protein 3 (NUDCD3) is a protein from Homo sapiens identified by UniProt accession Q8IVD9, 361 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	NudC domain-containing protein 3
UniProt accession	Q8IVD9
Gene	NUDCD3
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.18
neurodegenerative disease · score 0.18
hyperinsulinism due to INSR deficiency · score 0.06
hyperinsulinism-hyperammonemia syndrome · score 0.06
low density lipoprotein cholesterol measurement · score 0.05
hyperinsulinism due to glucokinase deficiency · score 0.05
MODY · score 0.05
exercise-induced hyperinsulinism · score 0.04
diabetes mellitus, permanent neonatal 4 · score 0.04
diabetes mellitus, transient neonatal, 3 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IVD9-F1	alphafold	PREDICTED	79.46	—

Amino-acid sequence (361 residues)

METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR MGFPPGAAQA LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS AAAAEKEPVP VPVQEIEIDS TTELDGHQEV EKVQPPGPVK EMAHGSQEAE APGAVAGAAE VPREPPILPR IQEQFQKNPD SYNGAVRENY TWSQDYTDLE VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG KLTHKINTES SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA MFNISPGAVQ F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards