About NUT family member 2A
NUT family member 2A (NUTM2A) is a protein
from Homo sapiens identified by UniProt accession
Q8IVF1, 878 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | NUT family member 2A |
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| UniProt accession | Q8IVF1 |
|---|
| Gene | NUTM2A |
|---|
| Organism | Homo sapiens |
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| Length | 878 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (104)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- hemoglobin measurement · score 0.08
- urate measurement · score 0.08
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- breast cancer · score 0.07
- creatinine measurement · score 0.07
- Female infertility due to fertilization defect · score 0.07
- Rare genetic female infertility · score 0.07
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVF1-F1 | alphafold | PREDICTED | 46.26 | — |
Amino-acid sequence (878 residues)
MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAKALH RMSPTPNSCP LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSHCGN CQTAVVSAQP EGMASNGAYP ALGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST LPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP WPQGAHGEGS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK QREEGEVKQP QEEDWTPPDP GLLSYTDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF LALSQELEQE EGLTLAQLVE KRLLPLKEKQ HARAAPSRGT ARLDSSSSKF AAGQGAERDV PVPQQGVGME TCPPQTTARD SQGRGRAHTG MARSKDSVVL LGCQDSPGLR AARPTSPPQD HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP VPASGLLSPE KWGPQGTHQF PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPHPGPGL RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQRCSQ
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