About Rho guanine nucleotide exchange factor TIAM2
Rho guanine nucleotide exchange factor TIAM2 (TIAM2) is a protein
from Homo sapiens identified by UniProt accession
Q8IVF5, 1701 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor TIAM2 |
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| UniProt accession | Q8IVF5 |
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| Gene | TIAM2 |
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| Organism | Homo sapiens |
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| Length | 1701 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.51
- vital capacity · score 0.49
- bone quantitative ultrasound measurement · score 0.41
- optic cup area measurement · score 0.34
- brain measurement · score 0.32
- forced expiratory volume · score 0.27
- lean body mass · score 0.25
- body height · score 0.25
- bone density · score 0.25
- urate measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVF5-F1 | alphafold | PREDICTED | 56.14 | — |
Amino-acid sequence (1701 residues)
MGNSDSQYTL QGSKNHSNTI TGAKQIPCSL KIRGIHAKEE KSLHGWGHGS NGAGYKSRSL ARSCLSHFKS NQPYASRLGG PTCKVSRGVA YSTHRTNAPG KDFQGISAAF STENGFHSVG HELADNHITS RDCNGHLLNC YGRNESIAST PPGEDRKSPR VLIKTLGKLD GCLRVEFHNG GNPSKVPAED CSEPVQLLRY SPTLASETSP VPEARRGSSA DSLPSHRPSP TDSRLRSSKG SSLSSESSWY DSPWGNAGEL SEAEGSFLAP GMPDPSLHAS FPPGDAKKPF NQSSSLSSLR ELYKDANLGS LSPSGIRLSD EYMGTHASLS NRVSFASDID VPSRVAHGDP IQYSSFTLPC RKPKAFVEDT AKKDSLKARM RRISDWTGSL SRKKRKLQEP RSKEGSDYFD SRSDGLNTDV QGSSQASAFL WSGGSTQILS QRSESTHAIG SDPLRQNIYE NFMRELEMSR TNTENIETST ETAESSSESL SSLEQLDLLF EKEQGVVRKA GWLFFKPLVT VQKERKLELV ARRKWKQYWV TLKGCTLLFY ETYGKNSMDQ SSAPRCALFA EDSIVQSVPE HPKKENVFCL SNSFGDVYLF QATSQTDLEN WVTAVHSACA SLFAKKHGKE DTLRLLKNQT KNLLQKIDMD SKMKKMAELQ LSVVSDPKNR KAIENQIQQW EQNLEKFHMD LFRMRCYLAS LQGGELPNPK SLLAAASRPS KLALGRLGIL SVSSFHALVC SRDDSALRKR TLSLTQRGRN KKGIFSSLKG LDTLARKGKE KRPSITQVDE LLHIYGSTVD GVPRDNAWEI QTYVHFQDNH GVTVGIKPEH RVEDILTLAC KMRQLEPSHY GLQLRKLVDD NVEYCIPAPY EYMQQQVYDE IEVFPLNVYD VQLTKTGSVC DFGFAVTAQV DERQHLSRIF ISDVLPDGLA YGEGLRKGNE IMTLNGEAVS DLDLKQMEAL FSEKSVGLTL IARPPDTKAT LCTSWSDSDL FSRDQKSLLP PPNQSQLLEE FLDNFKKNTA NDFSNVPDIT TGLKRSQTDG TLDQVSHREK MEQTFRSAEQ ITALCRSFND SQANGMEGPR ENQDPPPRSL ARHLSDADRL RKVIQELVDT EKSYVKDLSC LFELYLEPLQ NETFLTQDEM ESLFGSLPEM LEFQKVFLET LEDGISASSD FNTLETPSQF RKLLFSLGGS FLYYADHFKL YSGFCANHIK VQKVLERAKT DKAFKAFLDA RNPTKQHSST LESYLIKPVQ RVLKYPLLLK ELVSLTDQES EEHYHLTEAL KAMEKVASHI NEMQKIYEDY GTVFDQLVAE QSGTEKEVTE LSMGELLMHS TVSWLNPFLS LGKARKDLEL TVFVFKRAVI LVYKENCKLK KKLPSNSRPA HNSTDLDPFK FRWLIPISAL QVRLGNPAGT ENNSIWELIH TKSEIEGRPE TIFQLCCSDS ESKTNIVKVI RSILRENFRR HIKCELPLEK TCKDRLVPLK NRVPVSAKLA SSRSLKVLKN SSSNEWTGET GKGTLLDSDE GSLSSGTQSS GCPTAEGRQD SKSTSPGKYP HPGLADFADN LIKESDILSD EDDDHRQTVK QGSPTKDIEI QFQRLRISED PDVHPEAEQQ PGPESGEGQK GGEQPKLVRG HFCPIKRKAN STKRDRGTLL KAQIRHQSLD SQSENATIDL NSVLEREFSV QSLTSVVSEE CFYETESHGK S
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