About Ankyrin repeat domain-containing protein 18A
Ankyrin repeat domain-containing protein 18A (ANKRD18A) is a protein
from Homo sapiens identified by UniProt accession
Q8IVF6, 992 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 18A |
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| UniProt accession | Q8IVF6 |
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| Gene | ANKRD18A |
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| Organism | Homo sapiens |
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| Length | 992 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVF6-F1 | alphafold | PREDICTED | 71.36 | — |
Amino-acid sequence (992 residues)
MRKLFSFGRR LGQALLSSMD QEYAGPGYDI RDWELRKIHR AAIKGDAAEV ERCLTRRFRD LDARDRKDRT VLHLACAHGR VQVVTLLLHR RCQIDICDRL NRTPLMKAVH SQEEACAIVL LECGANPNIE DIYGNTALHY AVYNKGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIRISSQD MFGQTAEDYA LCSDLRSIRQ QILEHKNKML KNHLRNDNQE TAAMKPANLK KRKERAKAEH NLKVASEEKQ ERLQRSENKQ PQDSQSYGKK KDAMYGNFML KKDIAMLKEE LYAIKNDSLR KEKKYIQEIK SITEINANFE KSVRLNEKMI TKTVARYSQQ LNDLKAENAR LNSELEKEKH NKERLEAEVE SLHSSLATAI NEYNEIVERK DLELVLWRAD DVSRHEKMGS NISQLTDKNE LLTEQVHKAR VKFNTLKGKL RETRDALREK TLALGSVQLD LRQAQHRIKE MKQMHPNGEA KESQSIGKQN SLEERIRQQE LENLLLERQL EDARKEGDNK EIVINIHRDC LENGKEDLLE ERNKELMKEY NYLKEKLLQC EKEKAEREVI VREFQEELVD HLKTFSISES PLEGTSHCHI NLNETWTSKK KLFQVEIQPE EKHEEFRKLF ELISLLNYTA DQIRKKNREL EEEATGYKKC LEMTINMLNA FANEDFSCHG DLNTDQLKMD ILFKKLKQKF NDLVAEKEAV SSECVNLAKD NEVLHQELLS MRNVQEKCEK LEKDKKMLEE EVLNLKTHME KDMVELGKLQ EYKSELDERA VQEIEKLEEI HLQKQAEYEK QLEQLNKDNT ASLKKKELTL KDVECKFSKM KTAYEEVTTE LEEFKEAFAG AVKANNSMSK KLMKSDKKIA VISTKLFTEK QRMKYFLSTL PTRPEPELPC VENLNSIELN RKYIPKTAIR IPTSNPQTSN NCKNFLTEVL LC
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