About Forkhead box protein P4
Forkhead box protein P4 (FOXP4) is a protein
from Homo sapiens identified by UniProt accession
Q8IVH2, 680 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | Forkhead box protein P4 |
|---|
| UniProt accession | Q8IVH2 |
|---|
| Gene | FOXP4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 680 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (132)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Neurodevelopmental disorder · score 0.45
- ventricular septal defect · score 0.40
- prostate carcinoma · score 0.39
- sensorineural hearing loss · score 0.34
- Flattened epiphysis · score 0.34
- Sensorineural hearing impairment · score 0.34
- Short stature · score 0.34
- Hearing impairment · score 0.34
- lung adenocarcinoma · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVH2-F1 | alphafold | PREDICTED | 58.07 | — |
Amino-acid sequence (680 residues)
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP GPPLGAPNPS ASGPPEDRDL EEELPGEELS
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