About Methylmalonic aciduria type A protein, mitochondrial
Methylmalonic aciduria type A protein, mitochondrial (MMAA) is a protein
from Homo sapiens identified by UniProt accession
Q8IVH4, 418 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Methylmalonic aciduria type A protein, mitochondrial |
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| UniProt accession | Q8IVH4 |
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| Gene | MMAA |
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| Organism | Homo sapiens |
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| Length | 418 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (64)
Diseases linked to this target (Open Targets).
- methylmalonic aciduria, cblA type · score 0.84
- Vitamin B12-responsive methylmalonic acidemia type cblA · score 0.84
- methylmalonic acidemia · score 0.56
- Vitamin B12-responsive methylmalonic acidemia type cblB · score 0.37
- genetic disorder · score 0.19
- Severe global developmental delay · score 0.12
- Microcephaly · score 0.12
- cataract · score 0.12
- squamous cell lung carcinoma · score 0.11
- protein measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVH4-F1 | alphafold | PREDICTED | 78.50 | — |
Amino-acid sequence (418 residues)
MPMLLPHPHQ HFLKGLLRAP FRCYHFIFHS STHLGSGIPC AQPFNSLGLH CTKWMLLSDG LKRKLCVQTT LKDHTEGLSD KEQRFVDKLY TGLIQGQRAC LAEAITLVES THSRKKELAQ VLLQKVLLYH REQEQSNKGK PLAFRVGLSG PPGAGKSTFI EYFGKMLTER GHKLSVLAVD PSSCTSGGSL LGDKTRMTEL SRDMNAYIRP SPTRGTLGGV TRTTNEAILL CEGAGYDIIL IETVGVGQSE FAVADMVDMF VLLLPPAGGD ELQGIKRGII EMADLVAVTK SDGDLIVPAR RIQAEYVSAL KLLRKRSQVW KPKVIRISAR SGEGISEMWD KMKDFQDLML ASGELTAKRR KQQKVWMWNL IQESVLEHFR THPTVREQIP LLEQKVLIGA LSPGLAADFL LKAFKSRD
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