Neuron navigator 3 (NAV3)

About Neuron navigator 3

Neuron navigator 3 (NAV3) is a protein from Homo sapiens identified by UniProt accession Q8IVL0, 2385 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Neuron navigator 3
UniProt accession	Q8IVL0
Gene	NAV3
Organism	Homo sapiens
Length	2385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

platelet count · score 0.42
cortical surface area measurement · score 0.40
neuroimaging measurement · score 0.38
heel bone mineral density · score 0.38
refractive error measurement · score 0.36
platelet crit · score 0.36
brain measurement · score 0.35
cortical thickness · score 0.34
BMI-adjusted waist-hip ratio · score 0.33
body height · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IVL0-F1	alphafold	PREDICTED	47.18	—

Amino-acid sequence (2385 residues)

MPVLGVASKL RQPAVGSKPV HTALPIPNLG TTGSQHCSSR PLELTETESS MLSCQLALKS TCEFGEKKPL QGKAKEKEDS KIYTDWANHY LAKSGHKRLI KDLQQDIADG VLLAEIIQII ANEKVEDING CPRSQSQMIE NVDVCLSFLA ARGVNVQGLS AEEIRNGNLK AILGLFFSLS RYKQQQHHQQ QYYQSLVELQ QRVTHASPPS EASQAKTQQD MQSSLAARYA TQSNHSGIAT SQKKPTRLPG PSRVPAAGSS SKVQGASNLN RRSQSFNSID KNKPPNYANG NEKDSSKGPQ SSSGVNGNVQ PPSTAGQPPA SAIPSPSASK PWRSKSMNVK HSATSTMLTV KQSSTATSPT PSSDRLKPPV SEGVKTAPSG QKSMLEKFKL VNARTALRPP QPPSSGPSDG GKDDDAFSES GEMEGFNSGL NSGGSTNSSP KVSPKLAPPK AGSKNLSNKK SLLQPKEKEE KNRDKNKVCT EKPVKEEKDQ VTEMAPKKTS KIASLIPKGS KTTAAKKESL IPSSSGIPKP GSKVPTVKQT ISPGSTASKE SEKFRTTKGS PSQSLSKPIT MEKASASSCP APLEGREAGQ ASPSGSCTMT VAQSSGQSTG NGAVQLPQQQ QHSHPNTATV APFIYRAHSE NEGTALPSAD SCTSPTKMDL SYSKTAKQCL EEISGEDPET RRMRTVKNIA DLRQNLEETM SSLRGTQISH STLETTFDST VTTEVNGRTI PNLTSRPTPM TWRLGQACPR LQAGDAPSLG AGYPRSGTSR FIHTDPSRFM YTTPLRRAAV SRLGNMSQID MSEKASSDLD MSSEVDVGGY MSDGDILGKS LRTDDINSGY MTDGGLNLYT RSLNRIPDTA TSRDIIQRGV HDVTVDADSW DDSSSVSSGL SDTLDNISTD DLNTTSSVSS YSNITVPSRK NTQLRTDSEK RSTTDETWDS PEELKKPEED FDSHGDAGGK WKTVSSGLPE DPEKAGQKAS LSVSQTGSWR RGMSAQGGAP SRQKAGTSAL KTPGKTDDAK ASEKGKAPLK GSSLQRSPSD AGKSSGDEGK KPPSGIGRST ATSSFGFKKP SGVGSSAMIT SSGATITSGS ATLGKIPKSA AIGGKSNAGR KTSLDGSQNQ DDVVLHVSSK TTLQYRSLPR PSKSSTSGIP GRGGHRSSTS SIDSNVSSKS AGATTSKLRE PTKIGSGRSS PVTVNQTDKE KEKVAVSDSE SVSLSGSPKS SPTSASACGA QGLRQPGSKY PDIASPTFRR LFGAKAGGKS ASAPNTEGVK SSSVMPSPST TLARQGSLES PSSGTGSMGS AGGLSGSSSP LFNKPSDLTT DVISLSHSLA SSPASVHSFT SGGLVWAANM SSSSAGSKDT PSYQSMTSLH TSSESIDLPL SHHGSLSGLT TGTHEVQSLL MRTGSVRSTL SESMQLDRNT LPKKGLRYTP SSRQANQEEG KEWLRSHSTG GLQDTGNQSP LVSPSAMSSS AAGKYHFSNL VSPTNLSQFN LPGPSMMRSN SIPAQDSSFD LYDDSQLCGS ATSLEERPRA ISHSGSFRDS MEEVHGSSLS LVSSTSSLYS TAEEKAHSEQ IHKLRRELVA SQEKVATLTS QLSANAHLVA AFEKSLGNMT GRLQSLTMTA EQKESELIEL RETIEMLKAQ NSAAQAAIQG ALNGPDHPPK DLRIRRQHSS ESVSSINSAT SHSSIGSGND ADSKKKKKKN WVNSRGSELR SSFKQAFGKK KSTKPPSSHS DIEELTDSSL PASPKLPHNA GDCGSASMKP SQSASASPLV WPPKKRQNGP VIYKHRSRIC ECTEAEAEII LQLKSELREK ELKLTDIRLE ALSSAHHLDQ IREAMNRMQN EIEILKAEND RLKAETGNTA KPTRPPSESS SSTSSSSSRQ SLGLSLNNLN ITEAVSSDIL LDDAGDATGH KDGRSVKIIV SISKGYGRAK DQKSQAYLIG SIGVSGKTKW DVLDGVIRRL FKEYVFRIDT STSLGLSSDC IASYCIGDLI RSHNLEVPEL LPCGYLVGDN NIITVNLKGV EENSLDSFVF DTLIPKPITQ RYFNLLMEHH RIILSGPSGT GKTYLANKLA EYVITKSGRK KTEDAIATFN VDHKSSKELQ QYLANLAEQC SADNNGVELP VVIILDNLHH VGSLSDIFNG FLNCKYNKCP YIIGTMNQGV SSSPNLELHH NFRWVLCANH TEPVKGFLGR YLRRKLIEIE IERNIRNNDL VKIIDWIPKT WHHLNSFLET HSSSDVTIGP RLFLPCPMDV EGSRVWFMDL WNYSLVPYIL EAVREGLQMY GKRTPWEDPS KWVLDTYPWS SATLPQESPA LLQLRPEDVG YESCTSTKEA TTSKHIPQTD TEGDPLMNML MKLQEAANYS STQSCDSEST SHHEDILDSS LESTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards