About Prolyl 3-hydroxylase 2
Prolyl 3-hydroxylase 2 (P3H2) is a protein
from Homo sapiens identified by UniProt accession
Q8IVL5, 708 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Prolyl 3-hydroxylase 2 |
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| UniProt accession | Q8IVL5 |
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| Gene | P3H2 |
|---|
| Organism | Homo sapiens |
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| Length | 708 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- Rare isolated myopia · score 0.72
- platelet count · score 0.45
- body height · score 0.39
- platelet component distribution width · score 0.39
- platelet crit · score 0.38
- retinitis pigmentosa · score 0.33
- cleft lip · score 0.32
- alternating hemiplegia of childhood · score 0.32
- osteoarthritis, hip · score 0.29
- balding measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVL5-F1 | alphafold | PREDICTED | 83.39 | — |
Amino-acid sequence (708 residues)
MRERIWAPPL LLLLPLLLPP PLWGGPPDSP RRELELEPGP LQPFDLLYAS GAAAYYSGDY ERAVRDLEAA LRSHRRLREI RTRCARHCAA RHPLPPPPPG EGPGAELPLF RSLLGRARCY RSCETQRLGG PASRHRVSED VRSDFQRRVP YNYLQRAYIK LNQLEKAVEA AHTFFVANPE HMEMQQNIEN YRATAGVEAL QLVDREAKPH MESYNAGVKH YEADDFEMAI RHFEQALREY FVEDTECRTL CEGPQRFEEY EYLGYKAGLY EAIADHYMQV LVCQHECVRE LATRPGRLSP IENFLPLHYD YLQFAYYRVG EYVKALECAK AYLLCHPDDE DVLDNVDYYE SLLDDSIDPA SIEAREDLTM FVKRHKLESE LIKSAAEGLG FSYTEPNYWI RYGGRQDENR VPSGVNVEGA EVHGFSMGKK LSPKIDRDLR EGGPLLYENI TFVYNSEQLN GTQRVLLDNV LSEEQCRELH SVASGIMLVG DGYRGKTSPH TPNEKFEGAT VLKALKSGYE GRVPLKSARL FYDISEKARR IVESYFMLNS TLYFSYTHMV CRTALSGQQD RRNDLSHPIH ADNCLLDPEA NECWKEPPAY TFRDYSALLY MNDDFEGGEF IFTEMDAKTV TASIKPKCGR MISFSSGGEN PHGVKAVTKG KRCAVALWFT LDPLYRELER IQADEVIAIL DQEQQGKHEL NINPKDEL
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