Carboxypeptidase O (CPO)

About Carboxypeptidase O

Carboxypeptidase O (CPO) is a protein from Homo sapiens identified by UniProt accession Q8IVL8, 374 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Carboxypeptidase O
UniProt accession	Q8IVL8
Gene	CPO
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.32
brain measurement · score 0.25
albuminuria · score 0.21
eosinophil count · score 0.18
eosinophil percentage of leukocytes · score 0.08
Crohn's disease · score 0.07
breast carcinoma · score 0.03
body fat percentage · score 0.02
insomnia · score 0.02
total blood protein measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IVL8-F1	alphafold	PREDICTED	87.65	—

Amino-acid sequence (374 residues)

MKPLLETLYL LGMLVPGGLG YDRSLAQHRQ EIVDKSVSPW SLETYSYNIY HPMGEIYEWM REISEKYKEV VTQHFLGVTY ETHPMYYLKI SQPSGNPKKI IWMDCGIHAR EWIAPAFCQW FVKEILQNHK DNSSIRKLLR NLDFYVLPVL NIDGYIYTWT TDRLWRKSRS PHNNGTCFGT DLNRNFNASW CSIGASRNCQ DQTFCGTGPV SEPETKAVAS FIESKKDDIL CFLTMHSYGQ LILTPYGYTK NKSSNHPEMI QVGQKAANAL KAKYGTNYRV GSSADILYAS SGSSRDWARD IGIPFSYTFE LRDSGTYGFV LPEAQIQPTC EETMEAVLSV LDDVYAKHWH SDSAGRVTSA TMLLGLLVSC MSLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards