FUN14 domain-containing protein 1 (FUNDC1)

About FUN14 domain-containing protein 1

FUN14 domain-containing protein 1 (FUNDC1) is a protein from Homo sapiens identified by UniProt accession Q8IVP5, 155 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.

Target properties

Protein name	FUN14 domain-containing protein 1
UniProt accession	Q8IVP5
Gene	FUNDC1
Organism	Homo sapiens
Length	155 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (139)

Diseases linked to this target (Open Targets).

cancer · score 0.09
hepatocellular carcinoma · score 0.08
myocardial infarction · score 0.08
neoplasm · score 0.08
breast cancer · score 0.08
Pallister-Hall syndrome · score 0.07
melorheostosis · score 0.07
Osteoporosis · score 0.06
osteoporosis · score 0.06
pyknoachondrogenesis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IVP5-F1	alphafold	PREDICTED	74.95	—

Amino-acid sequence (155 residues)

MATRNPPPQD YESDDDSYEV LDLTEYARRH QWWNRVFGHS SGPMVEKYSV ATQIVMGGVT GWCAGFLFQK VGKLAATAVG GGFLLLQIAS HSGYVQIDWK RVEKDVNKAK RQIKKRANKA APEINNLIEE ATEFIKQNIV ISSGFVGGFL LGLAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards