Glycerate kinase (GLYCTK)

About Glycerate kinase

Glycerate kinase (GLYCTK) is a protein from Homo sapiens identified by UniProt accession Q8IVS8, 523 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	Glycerate kinase
UniProt accession	Q8IVS8
Gene	GLYCTK
Organism	Homo sapiens
Length	523 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (101)

Diseases linked to this target (Open Targets).

D-glyceric aciduria · score 0.72
total blood protein measurement · score 0.23
platelet count · score 0.23
schizophrenia · score 0.17
blood protein measurement · score 0.16
platelet crit · score 0.15
calcium measurement · score 0.15
cystatin C measurement · score 0.15
BMI-adjusted waist-hip ratio · score 0.14
BMI-adjusted waist circumference · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IVS8-F1	alphafold	PREDICTED	90.32	—

Amino-acid sequence (523 residues)

MAAALQVLPR LARAPLHPLL WRGSVARLAS SMALAEQARQ LFESAVGAVL PGPMLHRALS LDPGGRQLKV RDRNFQLRQN LYLVGFGKAV LGMAAAAEEL LGQHLVQGVI SVPKGIRAAM ERAGKQEMLL KPHSRVQVFE GAEDNLPDRD ALRAALAIQQ LAEGLTADDL LLVLISGGGS ALLPAPIPPV TLEEKQTLTR LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVVSLI LSDVVGDPVE VIASGPTVAS SHNVQDCLHI LNRYGLRAAL PRSVKTVLSR ADSDPHGPHT CGHVLNVIIG SNVLALAEAQ RQAEALGYQA VVLSAAMQGD VKSMAQFYGL LAHVARTRLT PSMAGASVEE DAQLHELAAE LQIPDLQLEE ALETMAWGRG PVCLLAGGEP TVQLQGSGRG GRNQELALRV GAELRRWPLG PIDVLFLSGG TDGQDGPTEA AGAWVTPELA SQAAAEGLDI ATFLAHNDSH TFFCCLQGGA HLLHTGMTGT NVMDTHLLFL RPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards