About Probable E3 ubiquitin-protein ligase HERC6
Probable E3 ubiquitin-protein ligase HERC6 (HERC6) is a protein
from Homo sapiens identified by UniProt accession
Q8IVU3, 1022 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase HERC6 |
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| UniProt accession | Q8IVU3 |
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| Gene | HERC6 |
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| Organism | Homo sapiens |
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| Length | 1022 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- gout · score 0.20
- blood metabolite measurement · score 0.12
- breast carcinoma · score 0.12
- linear and whorled nevoid hypermelanosis · score 0.05
- eosinophil peroxidase deficiency · score 0.05
- chronic myeloproliferative disorder · score 0.05
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- thrombocytopenia 4 · score 0.05
- chronic myelogenous leukemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVU3-F1 | alphafold | PREDICTED | 86.37 | — |
Amino-acid sequence (1022 residues)
MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPK KIMTLNDIKI IQVSCGHYHS LALSKDSQVF SWGKNSHGQL GLGKEFPSQA SPQRVRSLEG IPLAQVAAGG AHSFALSLCG TSFGWGSNSA GQLALSGRNV PVQSNKPLSV GALKNLGVVY ISCGDAHTAV LTQDGKVFTF GDNRSGQLGY SPTPEKRGPQ LVERIDGLVS QIDCGSYHTL AYVHTTGQVV SFGHGPSDTS KPTHPEALTE NFDISCLISA EDFVDVQVKH IFAGTYANFV TTHQDTSSTR APGKTLPEIS RISQSMAEKW IAVKRRSTEH EMAKSEIRMI FSSPACLTAS FLKKRGTGET TSIDVDLEMA RDTFKKLTKK EWISSMITTC LEDDLLRALP CHSPHQEALS VFLLLPECPV MHDSKNWKNL VVPFAKAVCE MSKQSLQVLK KCWAFLQESS LNPLIQMLKA AIISQLLHQT KTEQDHCNVK ALLGMMKELH KVNKANCRLP ENTFNINELS NLLNFYIDRG RQLFRDNHLI PAETPSPVIF SDFPFIFNSL SKIKLLQADS HIKMQMSEKK AYMLMHETIL QKKDEFPPSP RFILRVRRSR LVKDALRQLS QAEATDFCKV LVVEFINEIC PESGGVSSEF FHCMFEEMTK PEYGMFMYPE MGSCMWFPAK PKPEKKRYFL FGMLCGLSLF NLNVANLPFP LALYKKLLDQ KPSLEDLKEL SPRLGKSLQE VLDDAADDIG DALCIRFSIH WDQNDVDLIP NGISIPVDQT NKRDYVSKYI DYIFNVSVKA VYEEFQRGFY RVCEKEILRH FYPEELMTAI IGNTDYDWKQ FEQNSKYEQG YQKSHPTIQL FWKAFHKLTL DEKKKFLFFL TGRDRLHARG IQKMEIVFRC PETFSERDHP TSITCHNILS LPKYSTMERM EEALQVAINN NRGFVSPMLT QS
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