About Lipoxygenase homology domain-containing protein 1
Lipoxygenase homology domain-containing protein 1 (LOXHD1) is a protein
from Homo sapiens identified by UniProt accession
Q8IVV2, 2067 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Lipoxygenase homology domain-containing protein 1 |
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| UniProt accession | Q8IVV2 |
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| Gene | LOXHD1 |
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| Organism | Homo sapiens |
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| Length | 2067 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVV2-F1 | alphafold | PREDICTED | 83.71 | — |
Amino-acid sequence (2067 residues)
MMPQKKRRRK KDIDFLALYE AELLNYASED DEGELEHEYY KARVYEVVTA TGDVRGAGTD ANVFITLFGE NGLSPKLQLT SKSKSAFEKG NVDVFRVRTN NVGLIYKVRI EHDNTGLNAS WYLDHVIVTD MKRPHLRYYF NCNNWLSKVE GDRQWCRDLL ASFNPMDMPR GNKYEVKVYT GDVIGAGTDA DVFINIFGEY GDTGERRLEN EKDNFEKGAE DRFILDAPDL GQLMKINVGH NNKGGSAGWF LSQIVIEDIG NKRKYDFPLN RWLALDEDDG KIQRDILVGG AETTAITYIV TVFTGDVRGA GTKSKIYLVM YGARGNKNSG KIFLEGGVFD RGRTDIFHIE LAVLLSPLSR VSVGHGNVGV NRGWFCEKVV ILCPFTGIQQ TFPCSNWLDE KKADGLIERQ LYEMVSLRKK RLKKFPWSLW VWTTDLKKAG TNSPIFIQIY GQKGRTDEIL LNPNNKWFKP GIIEKFRIEL PDLGRFYKIR VWHDKRSSGS GWHLERMTLM NTLNKDKYNF NCNRWLDANE DDNEIVREMT AEGPTVRRIM GMARYHVTVC TGELEGAGTD ANVYLCLFGD VGDTGERLLY NCRNNTDLFE KGNADEFTIE SVTMRNVRRV RIRHDGKGSG SGWYLDRVLV REEGQPESDN VEFPCLRWLD KDKDDGQLVR ELLPSDSSAT LKNFRYHISL KTGDVSGAST DSRVYIKLYG DKSDTIKQVL LVSDNNLKDY FERGRVDEFT LETLNIGNIN RLVIGHDSTG MHASWFLGSV QIRVPRQGKQ YTFPANRWLD KNQADGRLEV ELYPSEVVEI QKLVHYEVEI WTGDVGGAGT SARVYMQIYG EKGKTEVLFL SSRSKVFERA SKDTFQTDTF TIYAIDLGAL TKIRIRHDNT GNRAGWFLDR IDITDMNNEI TYYFPCQRWL AVEEDDGQLS RELLPVDESY VLPQSEEGRG GGDNNPLDNL ALEQKDKSTT FSVTIKTGVK KNAGTDANVF ITLFGTQDDT GMTLLKSSKT NSDKFERDSI EIFTVETLDL GDLWKVRLGH DNTGKAPGWF VDWVEVDAPS LGKCMTFPCG RWLAKNEDDG SIIRDLFHAE LQTRLYTPFV PYEITLYTSD VFAAGTDANI FIIIYGCDAV CTQQKYLCTN KREQKQFFER KSASRFIVEL EDVGEIIEKI RIGHNNTGMN PGWHCSHVDI RRLLPDKDGA ETLTFPCDRW LATSEDDKKT IRELVPYDIF TEKYMKDGSL RQVYKEVEEP LDIVLYSVQI FTGNIPGAGT DAKVYITIYG DLGDTGERYL GKSENRTNKF ERGTADTFII EAADLGVIYK IKLRHDNSKW CADWYVEKVE IWNDTNEDEF LFLCGRWLSL KKEDGRLERL FYEKEYTGDR SSNCSSPADF WEIALSSKMA DVDISTVTGP MADYVQEGPI IPYYVSVTTG KHKDAATDSR AFIFLIGEDD ERSKRIWLDY PRGKRGFSRG SVEEFYVAGL DVGIIKKIEL GHDGASPESC WLVEELCLAV PTQGTKYMLN CNCWLAKDRG DGITSRVFDL LDAMVVNIGV KVLYEMTVWT GDVVGGGTDS NIFMTLYGIN GSTEEMQLDK KKARFEREQN DTFIMEILDI APFTKMRIRI DGLGSRPEWF LERILLKNMN TGDLTMFYYG DWLSQRKGKK TLVCEMCAVI DEEEMMEWTS YTVAVKTSDI LGAGTDANVF IIIFGENGDS GTLALKQSAN WNKFERNNTD TFNFPDMLSL GHLCKLRVWH DNKGIFPGWH LSYVDVKDNS RDETFHFQCD CWLSKSEGDG QTVRDFACAN NKICDELEET TYEIVIETGN GGETRENVWL ILEGRKNRSK EFLMENSSRQ RAFRKGTTDT FEFDSIYLGD IASLCVGHLA REDRFIPKRE LAWHVKTITI TEMEYGNVYF FNCDCLIPLK RKRKYFKVFE VTKTTESFAS KVQSLVPVKY EVIVTTGYEP GAGTDANVFV TIFGANGDTG KRELKQKMRN LFERGSTDRF FLETLELGEL RKVRLEHDSS GYCSGWLVEK VEVTNTSTGV ATIFNCGRWL DKKRGDGLTW RDLFPSV
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