Glucose-induced degradation protein 4 homolog (GID4)

About Glucose-induced degradation protein 4 homolog

Glucose-induced degradation protein 4 homolog (GID4) is a protein from Homo sapiens identified by UniProt accession Q8IVV7, 300 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Glucose-induced degradation protein 4 homolog
UniProt accession	Q8IVV7
Gene	GID4
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.28
BMI-adjusted waist-hip ratio · score 0.22
autism spectrum disorder · score 0.20
attention deficit hyperactivity disorder · score 0.19
bipolar disorder · score 0.19
obsessive-compulsive disorder · score 0.19
Tourette syndrome · score 0.19
unipolar depression · score 0.19
anorexia nervosa · score 0.19
systolic blood pressure · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IVV7-F1	alphafold	PREDICTED	74.37	—

Amino-acid sequence (300 residues)

MCARGQVGRG TQLRTGRPCS QVPGSRWRPE RLLRRQRAGG RPSRPHPARA RPGLSLPATL LGSRAAAAVP LPLPPALAPG DPAMPVRTEC PPPAGASAAS AASLIPPPPI NTQQPGVATS LLYSGSKFRG HQKSKGNSYD VEVVLQHVDT GNSYLCGYLK IKGLTEEYPT LTTFFEGEII SKKHPFLTRK WDADEDVDRK HWGKFLAFYQ YAKSFNSDDF DYEELKNGDY VFMRWKEQFL VPDHTIKDIS GASFAGFYYI CFQKSAASIE GYYYHRSSEW YQSLNLTHVP EHSAPIYEFR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards