About Cyclin-dependent kinase-like 3
Cyclin-dependent kinase-like 3 (CDKL3) is a protein
from Homo sapiens identified by UniProt accession
Q8IVW4, 592 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase-like 3 |
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| UniProt accession | Q8IVW4 |
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| Gene | CDKL3 |
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| Organism | Homo sapiens |
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| Length | 592 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.15
- childhood gender nonconformity · score 0.15
- mean platelet volume · score 0.12
- esophageal squamous cell carcinoma · score 0.09
- neoplasm · score 0.09
- osteosarcoma · score 0.07
- eosinophil count · score 0.07
- cholangiocarcinoma · score 0.07
- hepatocellular carcinoma · score 0.06
- asthma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVW4-F1 | alphafold | PREDICTED | 64.45 | — |
Amino-acid sequence (592 residues)
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW
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